Optimization, physicochemical characterization, and antimicrobial activity of a novel simvastatin nano-niosomal gel against E. coli and S. aureus

Niosomes, as a kind of drug delivery system, is widely used for the topical lipophilic drugs. Optimization niosomes plays an essential role in enhancing their therapeutic efficiencies. This study aims to prepare optimized niosomal formulation simvastatin (nSIM), member statins, through experiment (Response Surface methodology). Optimized were characterized size, polydispersity index (PDI), entrapment efficiency (EE), stability, releasing pattern, and antimicrobial activity. The different molar ratio surfactant cholesterol applied various loaded niosome. Mean particle size distribution analyzed by dynamic light scattering. Antibacterial activity was determined MIC MBC tests against Staphylococcus aureus Escherichia coli. release rate from noisome nanoparticles studied Franz diffusion cell method. pattern zero order, first Higuchi, Korsmeyer-Peppas, Hixson-Crowell kinetics models. obtained span 80, 0.4 with 7 min sonication time. PDI, zeta potential, (EE%) nSIM about 168 nm, 0.34, -32.40, 96 %, respectively. significantly decreased drug's enhanced antibacterial S. E. Coli. It found that followed Higuchi kinetic model which means diffusion. Overall, our findings indicated prepared showed good stability biological properties than free drug. Our suggests could be considered promising strategy poor water-soluble drugs enhance